Nathan Fillion was born in Edmonton, Alberta, Canada on March 27, 1971. His parents were both teachers and Nathan suspected that he would be one as well. However, he decided to become an actor and started working in theatre, television and film. In 1994 he landed the contract role of Joey Buchanan on the long-running soap One Life to Live. He was nominated for the Emmy in the category of Outstanding Younger Actor his his portrayel. He left the soap on the advice of co-star Bob Woods, who told him they would always have him back. Nathan then went on to appear in a small role in Steven Spielberg's Saving Private Ryan. He also joined the cast of Two Guys and a Girl on ABC.

In 2002, Nathan was cast in the role that would change him forever. For the new television series Firefly, Nathan was cast in the role of Captain Malcolm Reynolds. Though the show only ran for roughly half a season, it gained a huge following. Nathan again worked with show creator Joss Whedon when he guest starred as Caleb on Buffy the Vampire Slayer. Since Firefly, he has lent his voice to the animated show King of the Kill, Justice League Unlimited and the video games Jade Empire and Halo 3.

A film based on Firefly, called Serenity, was released in theaters in 2005. Nathan went on to appear in White Noise 2: the Light and an episode of the series Lost. In 2006 the horror comedy Slither was released. Nathan appeared opposite Keri Russell in the indie hit Waitress, which premiered at the Sundance Film Festival. In the spring of 2007, Nathan starred on the show Drive. FOX, the same network that cancelled Firefly, cancelled Drive after only a handful of episodes. For the 10,000 episode of One Life to Live n August 2007, Nathan reprised his role of Joey Buchanen for two days. In the fall of 2007, he joined the cast of Desperate Housewives in the role of Dr. Adam Mayfair. 2008 saw Nathan re-teaming with two directors he'd worked with previously. With Joss Whedon, Nathan worked on the internet series music Dr. Horrible's Sing-Along Blog playing the role of Captain Hammer. He worked again with James Gunn on the internest series PG Porn - for people who love everything about porn, except the sex.